COL25A1 Polyclonal Antibody

Product Specifications

Background

Collagen type XXV alpha 1 chain (COL25A1) Homo sapiens This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410) . A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Product Name Alternative

COL25A1; Collagen alpha-1 (XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P

Gene ID

84570

Swiss Prot

Q9BXS0

Cross Reactivity

Human; Mouse

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC-p; IF/ICC; ELISA

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Molecular Weight

Storage Conditions

-20°C/1 year

Protein Weight

Available Sizes

Curated Selection

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MBS1028700-01 0.02 mg (E-Coli)

Recombinant Clostridium botulinum Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)

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