Caspase-3 Polyclonal Antibody
Product Specifications
Background
Caspase 3 (CASP3) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Product Name Alternative
CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1; YM3435
Gene ID
836
Swiss Prot
P42574
Cross Reactivity
Human; Chicken (testedbyourcustomer)
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC-p; IF (paraffin section)
Dilution
WB: 1:1000-2000 IHC: 1:200-500
Buffer
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Molecular Weight
35
Storage Conditions
-20°C/1 year
Protein Weight
35
Available Sizes
Curated Selection
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