Bob 1 Polyclonal Antibody

Product Specifications

Background

Disease:A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27; q23) with BCL6., function:Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers., PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation., similarity:Belongs to the POU2AF1 family., tissue specificity:B-cell specific.

Product Name Alternative

POU domain class 2-associating factor 1 (B-cell-specific coactivator OBF-1; BOB-1; OCA-B; OCT-binding factor 1)

Gene ID

5450

Swiss Prot

Q16633

Cross Reactivity

Human; Rat; Mouse

Clonality

Polyclonal

Source

Rabbit

Applications

IHC-p; IF (paraffin section) ; ELISA

Dilution

IHC-p 1:50-200, ELISA 1:10000-20000

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Conditions

-20°C/1 year