BAM32 (phospho Tyr139) Polyclonal Antibody

Function:May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR) -signaling downstream of PI3K., induction:Upon B-cell activation., PTM:Phosphorylated on tyrosine residues., similarity:Contains 1 PH domain., similarity:Contains 1 SH2 domain., subcellular location:Membrane-associated after cell stimulation leading to its translocation., subunit:Interacts with PtdIns (3,4,5) P3 and PLCG2. In vitro, interacts with PtdIns (3,4) P2., tissue specificity:Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.

DAPP1; BAM32; HSPC066; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; hDAPP1; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.