Isopteropodine

Isopteropodine is a positive modulator that selectively acts on muscarinic M1 and 5-HT2 receptors. Isopteropodine has an EC50 of 9.92 μM for acetylcholine and 14.5 μM for 5-HT. Isopteropodine also has antibacterial activity against Gram-positive bacteria, with MICs of 150 μg/mL and 250 μg/mL for Staphylococcus aureus and Bacillus subtilis, respectively. Isopteropodine enhances receptor function by increasing the affinity of agonists for receptors and can also inhibit the growth of specific Gram-positive bacteria, and can be used in cognitive impairment and antibacterial research[1][2].

Product Specifications

CAS Number

[5171-37-9]

UNSPSC

12352005

Hazard Statement

H300

Target

5-HT Receptor; Bacterial; mAChR

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/isopteropodine.html

Purity

99.13

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CO[C@@H](C)[C@]([C@]1([H])C[C@]23[H])([H])CN2CC[C@]43C(NC5=C4C=CC=C5)=O)OC

Molecular Formula

C21H24N2O4

Molecular Weight

368.43

Precautions

H300

References & Citations

[1]Kang TH, et al. Pteropodine and isopteropodine positively modulate the function of rat muscarinic M (1) and 5-HT (2) receptors expressed in Xenopus oocyte. Eur J Pharmacol. 2002 May 24;444 (1-2) :39-45.|[2]García R, et al. Antimicrobial activity of isopteropodine. Z Naturforsch C J Biosci. 2005 May-Jun;60 (5-6) :385-8.