Alix Polyclonal Antibody
Product Specifications
Background
Programmed cell death 6 interacting protein (PDCD6IP) Homo sapiens This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]
Product Name Alternative
Programmed cell death 6-interacting protein (PDCD6-interacting protein; ALG-2-interacting protein 1; Hp95)
Gene ID
10015
Swiss Prot
Q8WUM4
Cross Reactivity
Human; Rat; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
WB 1:500-2000, ELISA (peptide) 1:5000-20000
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
85-100
Storage Conditions
-20°C/1 year
Protein Weight
85-100
Available Sizes
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