AGRP rabbit pAb

Disease:Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665]., domain:The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin., function:Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding., similarity:Contains 1 agouti domain., tissue specificity:Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.