CD284 Polyclonal Antibody
Product Specifications
Background
Toll like receptor 4 (TLR4) Homo sapiens The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Product Name Alternative
TLR4; Toll-like receptor 4; hToll; CD antigen CD284
Gene ID
7099
Swiss Prot
O00206
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
IF/ICC; WB; IHC-p; ELISA
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
95
Storage Conditions
-20°C/1 year
Protein Weight
95
Available Sizes
Curated Selection
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