Phospho-MLKL (S358) mouse Monoclonal Antibody (6B4)
Product Specifications
Background
Mixed lineage kinase domain like (MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Product Name Alternative
MLKL
Gene ID
197259
Swiss Prot
Q8NB16
Cross Reactivity
Human
Clonality
Monoclonal
Source
Mouse
Applications
IHC-p; IF (paraffin section)
Dilution
Western Blot: 1/500 - 1/2000.IHC-p:1:50-200. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
54
Storage Conditions
-20°C/1 year
Protein Weight
54
Available Sizes
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