Noggin mouse mAb
Product Specifications
Background
Noggin (NOG) Homo sapiens The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4) . By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and mu
Product Name Alternative
NOG; NOGG_HUMAN; Noggin; SYM 1; SYM1; Symphalangism 1 (proximal) ; Synostoses (multiple) syndrome 1; SYNS 1; SYNS1.
Gene ID
9241
Swiss Prot
Q13253
Clonality
Monoclonal
Source
Mouse
Applications
WB; ICC
Dilution
Wb 1:1000 icc 1:100
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
26
Storage Conditions
-20°C/1 year
Protein Weight
26
Available Sizes
Curated Selection
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