KLHL12 Monoclonal Antibody

Product Specifications

Background

Kelch like family member 12 (KLHL12) Homo sapiens This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Product Name Alternative

KLHL12; C3IP1; Kelch-like protein 12; CUL3-interacting protein 1; DKIR homolog; hDKIR

Gene ID

59349

Swiss Prot

Q53G59

Cross Reactivity

Human

Clonality

Monoclonal

Source

Mouse

Applications

WB; ELISA

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Buffer

Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

Storage Conditions

-20°C/1 year