Crk II Monoclonal Antibody
Product Specifications
Background
CRK proto-oncogene, adaptor protein (CRK) Homo sapiens This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Product Name Alternative
CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
Gene ID
1398
Swiss Prot
P46108
Cross Reactivity
Human; Mouse; Dog; Rabbit
Clonality
Monoclonal
Source
Mouse
Applications
WB
Dilution
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
Buffer
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Storage Conditions
-20°C/1 year
Available Sizes
Curated Selection
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