CD16 Monoclonal Antibody (Q32)
Product Specifications
Background
Fc fragment of IgG receptor IIIa (FCGR3A) Homo sapiens This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Gene ID
2214/2215
Swiss Prot
P08637/O75015
Cross Reactivity
Human
Clonality
Monoclonal
Source
Mouse
Applications
WB; IHC-p; IF (paraffin section)
Dilution
WB: 1:1000 IHC 1:50-300
Buffer
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Molecular Weight
45
Storage Conditions
-20°C/1 year
Protein Weight
45
Available Sizes
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