AMPKβ1 Mouse mAb (Mix-mA)
Product Specifications
Background
Protein kinase AMP-activated non-catalytic subunit beta 1 (PRKAB1) Homo sapiens The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided
Product Name Alternative
5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb)
Gene ID
5564
Swiss Prot
Q9Y478
Cross Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Source
Mouse
Applications
IHC-p; WB
Dilution
IHC-p1:50-200 , WB 1:1000-2000
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.41% sodium azide.
Molecular Weight
38
Storage Conditions
-20°C/1 year
Protein Weight
38
Available Sizes
Curated Selection
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