TNF α Monoclonal Antibody (Q36)
Product Specifications
Background
Tumor necrosis factor (TNF) Homo sapiens This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
Product Name Alternative
Tumor necrosis factor (Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment; NTF) ; Intracellular domain 1 (ICD1) ; Intracellular domain 2 (ICD2) ; C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene ID
7124
Swiss Prot
P01375
Cross Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Source
Mouse
Applications
WB; IHC-p; IF (paraffin section)
Dilution
WB: 1:1000-1:3000 IHC: 1:50-1:200
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
17,25
Storage Conditions
-20°C/1 year
Protein Weight
17,25
Available Sizes
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