Catenin-β Monoclonal Antibody (4F2)
Product Specifications
Background
Catenin beta 1 (CTNNB1) Homo sapiens The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Product Name Alternative
CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin
Gene ID
1499
Swiss Prot
P35222
Cross Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Source
Mouse
Applications
WB; IF/ICC; IHC-p
Dilution
WB: 1:1000-2000 IHC: 1:200-500 IF 1:200
Buffer
PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Molecular Weight
92
Storage Conditions
-20°C/1 year
Protein Weight
92
Available Sizes
Curated Selection
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