IAG933

IAG933 (YAP-TEAD-IN-3) is an orally available YAP/TAZ-TEAD inhibitor that has anti-tumor effects and promotes apoptosis. IAG933 YAP-TEAD-IN-3 inhibits Avi-human TEAD4217-434, with an IC50 value of 9 nM[1][2].

Product Specifications

CAS Number

[2714434-21-4]

Product Name Alternative

YAP-TEAD-IN-3

UNSPSC

12352005

Target

Apoptosis; YAP

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/iag933-1.html

Purity

99.81

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

ClC(C(F)=CC1=C2C[C@](C3=CC=CC=C3)([C@@H]4CCCN4)O1)=[C@]2[C@@]5=C(C(NC)=O)C=NC(OCCO)=C5F

Molecular Formula

C27H26ClF2N3O4

Molecular Weight

529.96

References & Citations

[1]Bordas V, et al. Preparation of biaryl derivatives as YAP/TAZ-TEAD protein-protein interaction inhibitors. World Intellectual Property Organization, WO2021186324 A1. 2021-09-23.|[2]Emilie A Chapeau, et al. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer. 2024 Jul;5 (7) :1102-1120.