3-Nitro-L-tyrosine-d3
3-Nitro-L-tyrosine-d3 is the deuterium labeled 3-Nitro-L-tyrosine. 3-Nitro-L-tyrosine is a biomarker of nitrogen free radical species modified proteins in systemic autoimmunogenic conditions[1][2].
Product Specifications
CAS Number
213386-10-8
UNSPSC
12352005
Hazard Statement
H317, H319
Target
Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Purity
99.9
Solubility
10 mM in DMSO|H2O : 5mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)
Smiles
N[C@@H](CC1=C([2H])C([N+]([O-])=O)=C(O)C([2H])=C1[2H])C(O)=O
Molecular Formula
C9H7D3N2O5
Molecular Weight
229.20
Precautions
H317, H319
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Montoliu C, et al. 3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis. Am J Gastroenterol. 2011 Sep;106 (9) :1629-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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