4-Methylesculetin

4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases[1][2].

Product Specifications

CAS Number

[529-84-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cathepsin; Glutathione Peroxidase; Phosphatase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/4-methylesculetin.html

Concentration

10mM

Purity

99.27

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1C=C(C)C2=CC(O)=C(O)C=C2O1

Molecular Formula

C10H8O4

Molecular Weight

192.17

Precautions

H315, H319, H335

References & Citations

[1]Witaicenis A, et al. 4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation. Chem Biol Interact. 2018 Jan 25;280:59-63.|[2]Hemshekhar M, et al. Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative. Biochimie. 2013 Jun;95 (6) :1326-35.