Paltimatrectinib
Product Specifications
UNSPSC Description
Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of [1].
Target Antigen
Trk Receptor; Tyrosinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Neuronal Signaling;Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/paltimatrectinib.html
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 75°C)
Smiles
FC(F)(C1=CN(N=C1)C2=C3N(C=CC(N4[C@](C5=C(C=CC(F)=C5)F)([H])CCC4)=N3)N=C2)F
Molecular Weight
434.37
References & Citations
[1]Kollol Pal, et al. 5-(2-(2,5-difluorophenyl)pyrrolidin-1 -yl)-3-(1h-pyrazol-1-yl)pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer. WO2019118584A1.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145587/Paltimatrectinib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145587/Paltimatrectinib-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
2353522-15-1
Available Sizes
Curated Selection
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