Paltimatrectinib

Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of [1].

Product Specifications

CAS Number

[2353522-15-1]

Product Name Alternative

PBI-200; PPI-5278

UNSPSC

12352005

Target

Trk Receptor; Tyrosinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/paltimatrectinib.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 75°C)

Smiles

FC(F)(C1=CN(N=C1)C2=C3N(C=CC(N4[C@](C5=C(C=CC(F)=C5)F)([H])CCC4)=N3)N=C2)F

Molecular Formula

C20H15F5N6

Molecular Weight

434.37

References & Citations

[1]Kollol Pal, et al. 5- (2- (2,5-difluorophenyl) pyrrolidin-1 -yl) -3- (1h-pyrazol-1-yl) pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer. WO2019118584A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

TrkA

Available Sizes

Curated Selection

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