Paltimatrectinib
Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of [1].
Product Specifications
CAS Number
[2353522-15-1]
Product Name Alternative
PBI-200; PPI-5278
UNSPSC
12352005
Target
Trk Receptor; Tyrosinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/paltimatrectinib.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 75°C)
Smiles
FC(F)(C1=CN(N=C1)C2=C3N(C=CC(N4[C@](C5=C(C=CC(F)=C5)F)([H])CCC4)=N3)N=C2)F
Molecular Formula
C20H15F5N6
Molecular Weight
434.37
References & Citations
[1]Kollol Pal, et al. 5- (2- (2,5-difluorophenyl) pyrrolidin-1 -yl) -3- (1h-pyrazol-1-yl) pyrazolo[1,5-a]pyrimidine derivatives and related compounds as trk kinase inhibitors for treating cancer. WO2019118584A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
TrkA
Available Sizes
Curated Selection
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