Dopamine D2 receptor antagonist-1
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity[1].
Product Specifications
CAS Number
[1055411-77-2]
UNSPSC
12352005
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dopamine-d2-receptor-antagonist-1.html
Concentration
10mM
Purity
99.06
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C12=NC=NC(NC3CCC3)=C1C4=C(CCCC4)S2
Molecular Formula
C14H17N3S
Molecular Weight
259.37
References & Citations
[1]Fyfe TJ, et al. Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor. Eur J Med Chem. 2019 Apr 15;168:474-490.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D2 Receptor
Available Sizes
Curated Selection
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