Phospho-RSK1 (S380) [SC05-32] Antibody

The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, are important signaling intermediates that mediate responses to a broad range of ligand-activated receptor tyrosine kinases. It has been established that Rsk-3 is not activated by MAP kinase in vitro, unlike Rsk-1 and Rsk-2. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. The Rsk family amino-terminal kinase domain is phosphorylated on Ser 227 by 3-phosphoinositide-dependent protein kinase-1 (PDK1), which increases the kinase activity of Rsk. In the carboxy-terminal kinase domain, Rsk-1 and Rsk-2 are autophosphorylated on Ser 380 and Ser 386, respectively, which mediates the docking of PDK1 to Rsk in order to promote phosphorylation of substrates, such as histone H3.

Product Specifications

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Ser380 of human RSK1.

Modification

P-S380

Antibody Type

Primary Antibodies

Product Name Synonym

90 kDa ribosomal protein S6 kinase 1 antibody dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1 antibody dJ590P13.1 antibody EC 2.7.11.1 antibody HU 1 antibody HU1 antibody KS6A1_HUMAN antibody MAP kinase activated protein kinase 1a antibody MAP kinase-activated protein kinase 1a antibody MAPK-activated protein kinase 1a antibody MAPKAP kinase 1a antibody MAPKAPK-1a antibody MAPKAPK1A antibody MGC79981 antibody Mitogen-activated protein kinase-activated protein kinase 1A antibody OTTHUMP00000004113 antibody p90 RSK1 antibody p90-RSK 1 antibody p90rsk antibody p90RSK1 antibody p90S6K antibody pp90RSK1 antibody Ribosomal protein S6 kinase 90kD 1 antibody Ribosomal protein S6 kinase 90kD polypeptide 1 antibody Ribosomal protein S6 kinase 90kDa polypeptide 1 antibody Ribosomal protein S6 kinase alpha 1 antibody Ribosomal protein S6 kinase alpha-1 antibody Ribosomal protein S6 kinase polypeptide 1 antibody Ribosomal S6 kinase 1 antibody RPS6K1 alpha antibody rps6ka antibody Rps6ka1 antibody RSK 1 antibody RSK 1 p90 antibody RSK antibody RSK-1 antibody RSK1 antibody S6K alpha 1 antibody S6K-alpha-1 antibody