Sodium Potassium ATPase [ST0533] Antibody
The ubiquitously expressed sodium/potassium-ATPase (Na; +; /K; +; -ATPase) exists as an oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na; +; ions and two K; +; ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na; +; /K; +; -ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, α, β and γ, comprise the Na; +; /K; +; -ATPase oligomer. The α subunit contains the binding sites for ATP and the cations; the glycosylated β subunit ensures correct folding and membrane insertion of the α subunits. The small γ subunit co-localizes with the α subunit in nephron segments, where it increases the affinity of Na; +; /K; +; -ATPase for ATP. The β subunit, but not the γ subunit, is essential for normal activity of Na; +; /K; +; -ATPase.
Product Specifications
Immunogen
Recombinant protein
Antibody Type
Primary Antibodies
Product Name Synonym
Available Sizes
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