M6PR [SR45-09] Antibody
The mannose 6-phosphate/insulin-like growth factor II receptor, IGF-IIR (also designated M6P/IGF2R), is a ubiquitously expressed integral glycoprotein. By binding glycoproteins through two of its extracytoplasmic domains, IGF-IIR mediates the activation of TGF∫1 (a growth inhibitor), the degradation of IGF-II and the transport of lysosomal enzymes. Subsequently, IGF-IIR can form oligomeric complexes, which increase the affinity of IGF-IIR for lysosomal enzymes. Unlike IGF-IR, IGF-IIR does not potentiate the signaling of IGF-I or IGF-II, which have mitogenic, cell survival and insulin-like effects. Therefore, IGF-IIR is characterized as a tumor suppressor. Furthermore, the IGF-IIR gene is located on chromosome 6q26, which is commonly mutated or deleted in several human cancers.
Product Specifications
Immunogen
Recombinant protein
Antibody Type
Primary Antibodies
Product Name Synonym
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Jak1, NT (Jak1, Tyrosine-protein kinase JAK1, Janus kinase 1) (MaxLight 650) discontinued
