FITC Conjugated Human CD11b Recombinant Mouse Monoclonal Antibody [A2-9-R]
Selected Variant
HA600130F
Size: 100 µL
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ITGAM, CD11B, CR3A
Swiss Prot
P11215 Human, P05555 Mouse
Cellular Locus
Cell membrane.
Host
Mouse
Species Reactivity
Human, Mouse
Immunogen
Recombinant protein within Human CD11b aa 544-743 / 1,152.
Isotype
IgG1
Clone
A2-9-R
Conjugation
FITC-conjugated
Type
Recombinant Mouse monoclonal Antibody
Applications
FC
Positive Control
Mouse peripheral blood.
Dilution
FC: 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Purity
Protein G affinity purified.
Form
Liquid
Buffer
Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
Molecular Weight
Predicted band size: 127 kDa
Storage Conditions
Store at 2°C to 8°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
Price
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