FITC Conjugated Human CD11b Recombinant Mouse Monoclonal Antibody [A2-9-R]
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development.
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
ITGAM, CD11B, CR3A
Swiss Prot
P11215 Human, P05555 Mouse
Cellular Locus
Cell membrane.
Host
Mouse
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within Human CD11b aa 544-743 / 1,152.
Isotype
IgG1
Clone
A2-9-R
Conjugation
FITC-conjugated
Type
Recombinant Mouse monoclonal Antibody
Applications
FC
Positive Control
Mouse peripheral blood.
Dilution
FC: 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Purity
Protein G affinity purified.
Form
Liquid
Buffer
Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
Molecular Weight
Predicted band size: 127 kDa
Storage Conditions
Store at 2°C to 8°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
Yes
Frequently Asked Questions
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