PAOX Antibody

Catalytic activity:N (1), N (12) -diacetylspermine + O (2) + H (2) O = N (1) -acetylspermidine + 3-acetamidobutanal + H (2) O (2) . catalytic activity:N (1) -acetylspermidine + O (2) + H (2) O = putrescine + 3-acetamidopropanal + H (2) O (2) . catalytic activity:N (1) -acetylspermine + O (2) + H (2) O = spermidine + 3-acetamidopropanal + H (2) O (2) . cofactor:Binds 1 FAD per subunit. Flavoenzyme which catalyzes the oxidation of N (1) -acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N (1) -acetylspermidine to putrescine. Substrate specificity: N (1) -acetylspermine = N (1) -acetylspermidine > N (1), N (12) -diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. induction:By polyamine analogs. miscellaneous:Oxidizes N (1) -acetylated polyamines on the exo-side of their N (4) -amino groups. Plant PAO oxidizes spermine on the endo-side of the N (4) -nitrogen. pathway:Amine and polyamine metabolism; spermine metabolism. Belongs to the flavin monoamine oxidase family. subunit:Monomer. tissue specificity:Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.