Tip5 Antibody

May play a role in transcriptional regulation interacting with ISWI. May serve a specific role in maintaining or altering the chromatin structure of the rDNA locus. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. sequence caution:Contaminating sequence. Potential poly-A sequence. Belongs to the WAL family. Contains 1 bromo domain. Contains 1 DDT domain. Contains 1 MBD (methyl-CpG-binding) domain. Contains 1 PHD-type zinc finger. Contains 4 A. T hook DNA-binding domains. subcellular location:Colocalizes with the basal RNA polymerase I transcription factor UBF in the nucleolus. subunit:Together with SMARCA5, it forms a complex termed NoRC (nucleolar remodeling complex) . tissue specificity:Expressed at moderate levels in most tissues analyzed, including heart, brain, placenta, lung, skeletal muscle, kidney and pancreas.