SYT Antibody

Disease:A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t (X;18) (p11. 2; q11. 2) . The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency) . Belongs to the SS18 family. tissue specificity:Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.