Sck Antibody

Domain:The PID domain mediates binding to the TrkA receptor. Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576. PTM:Phosphorylated on tyrosines by the Trk receptors. Contains 1 PID domain. Contains 1 SH2 domain. subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.