Antipain (dihydrochloride)

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].

[1]DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77(11):6649-53.|[2]Suda H,et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo). 1972 Apr;25(4):263-6.|[3]Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63(6):768-76.|[4]Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42(4):624‐626.|[5]Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74(9):3754‐3757.