Antipain (dihydrochloride)

Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) -induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice[1][2][3][4].

Product Specifications

CAS Number

[37682-72-7]

UNSPSC

12352005

Target

DNA/RNA Synthesis; Ser/Thr Protease

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/antipain-dihydrochloride.html

Purity

99.9

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

OC([C@@H](NC(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(NC(C([H])=O)CCCNC(N)=N)=O)=O)=O)CC1=CC=CC=C1)=O.[H]Cl.[H]Cl

Molecular Formula

C27H46Cl2N10O6

Molecular Weight

677.62

References & Citations

[1]DiPaolo JA, et al. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. Proc Natl Acad Sci U S A. 1980 Nov;77 (11) :6649-53.|[2]Suda H, et al. Antipain, a new protease inhibitor isolated from actinomycetes. J Antibiot (Tokyo) . 1972 Apr;25 (4) :263-6.|[3]Sudha VT, et al. Identification of a serine protease as a major allergen (Per a 10) of Periplaneta americana. Allergy. 2008 Jun;63 (6) :768-76.|[4]Nomura T, et al. Inhibiting effects of antipain on urethane-induced lung neoplasia in mice. Br J Cancer. 1980;42 (4) :624‐626.|[5]Katz J, et al. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Proc Natl Acad Sci U S A. 1977;74 (9) :3754‐3757.