(E) -Flavokawain A

(E) -Flavokawain A, a chalcone extracted from Kava, has anticarcinogenic effect. (E) -Flavokawain A induces apoptosis in bladder cancer cells by involvement of bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice[1].

Product Specifications

CAS Number

[37951-13-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flavokawain-a.html

Purity

99.79

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(OC)C=C(OC)C=C1O)/C=C/C2=CC=C(OC)C=C2

Molecular Formula

C18H18O5

Molecular Weight

314.33

Precautions

H302, H315, H319

References & Citations

[1]Zi X, et al. Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice. Cancer Res. 2005 Apr 15;65 (8) :3479-86.