Caspase-8 (C-terminal region) Antibody
Product Specifications
Background
The caspases are a group of cysteine enzymes, which cleave proteins in response to intrinsic and extrinsic pathways that cause apoptotic cell death. The caspases can be grouped into two subgroups based on their roles in apoptosis. Initiator caspases (caspases 2, 8, 9, and 10) are activated through the apoptosis-signaling pathways and activate the effector caspases (caspases 3, 6, and 7) which carry out apoptosis. Caspase cascades are initiated through assembly of multiprotein complexes that trigger activation of the initiator caspases, which are then released and are able to activate the downstream effector caspases.
Synonyms
Caspase-8, ced3, NEDD2-like protein, p15, p10
Swiss Prot
Q14790
Host
Mouse
Cross Reactivity
Human
Target
Caspase-8 (C-terminal region)
Clonality
Monoclonal
Isotype
IgG2a
Clone
M382
Conjugation
Unconjugated
Source
Clone (M382) was generated from a recombinant protein containing amino acid residues in the C-terminal region of human Caspase-8.
Applications
WB
Purification
Purified by Protein A.
Dilution
WB (1:300-5000)
Buffer
PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Product Datasheet
https://www.biossantibodies.com/datasheets/bsm-70376M
Specificity
The antibody detects a 55 kDa* protein corresponding to the molecular weight of Caspase-8 on SDS-PAGE immunoblots of human Jurkat, K562, and A431 cells.
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