Tubulin, beta III Antibody

Product Specifications

Background

Tubulin is the major constituent of microtubules, existing as a heterodimer of the α and β subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990) . Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)

Synonyms

Beta 3 tubulin antibody, beta-4 antibody, beta III Tubulin, CDCBM antibody, CDCBM1 antibody, CFEOM3 antibody, CFEOM3A antibody, FEOM3 antibody, M (beta) 3 antibody, M (beta) 6 antibody, MC1R antibody, Neuron specific beta III Tubulin antibody, Neuron-specific class III beta-tubulin antibody, QccE-11995 antibody, QccE-15186 antibody, TBB3_HUMAN antibody, Tubb 3 antibody, TUBB3 antibody, TUBB4 antibody, Tubulin beta 3 antibody, Tubulin beta 3 chain antibody, Tubulin beta 4 antibody, Tubulin beta III antibody, Tubulin beta-3 chain antibody, Tubulin beta-4 chain antibody, Tubulin beta-III antibody

Gene ID

246118

Swiss Prot

Q4QRB4

Host

Mouse

Cross Reactivity

Mouse, Rat

Target

Tubulin, beta III

Clonality

Monoclonal

Isotype

IgG

Clone

AA10

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues specific to rat beta III tubulin, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

WB, IHC

Purification

Purified by Protein G.

Concentration

Lot Dependent

Dilution

WB (1:300-5000), IHC ()

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.