Thyroid Hormone Receptor, ß-Isotype Antibody

Product Specifications

Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000) . Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005) .

Synonyms

Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibody, C ERBA 2 antibody, C ERBA BETA antibody, c-erbA-2 antibody, c-erbA-beta antibody, ERBA 2 antibody, ERBA BETA antibody, ERBA2 antibody, Erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibody, generalized resistance to thyroid hormone antibody, GRTH antibody, MGC126109 antibody, MGC126110 antibody, NR1A2 antibody, Nuclear receptor subfamily 1 group A member 2 antibody, Oncogene ERBA2 antibody, PRTH antibody, THB_HUMAN antibody, THR1 antibody, THRB 1 antibody, THRB 2 antibody, thrB antibody, THRB1 antibody, THRB2 antibody, Thyroid hormone nuclear receptor beta variant 1 antibody, Thyroid hormone receptor beta 1 antibody, Thyroid hormone receptor beta 2 antibody, Thyroid hormone receptor beta antibody, Thyroid hormone receptor beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2 avian) antibody

Gene ID

7068

Swiss Prot

P10828

Host

Mouse

Cross Reactivity

Human

Target

Thyroid Hormone Receptor, ß-Isotype

Clonality

Monoclonal

Isotype

IgG1

Clone

2386

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, β-isotype, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Purified by Protein G.

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.