Thyroid Hormone Receptor, α2-Isotype Antibody

Product Specifications

Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000) . Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors, TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005) .

Synonyms

C-erbA-1 antibody, C-erbA-alpha antibody, EAR-7 antibody, ERBA 1 antibody, ERBA antibody, ERBA related 7 antibody, Nuclear receptor subfamily 1 group A member 1 antibody, THA_HUMAN antibody, THRA antibody, Thra1 antibody, Thra2 antibody, Thyroid hormone receptor alpha 1 antibody, Thyroid hormone receptor alpha 2 antibody, Thyroid hormone receptor alpha antibody, TR alpha 1 antibody, TR alpha 2 antibody, Tra1 antibody, Triiodothyronine receptor antibody, V-erbA-related protein 7 antibody

Gene ID

7067

Swiss Prot

P10827

Host

Mouse

Cross Reactivity

Human, Rat

Target

Thyroid Hormone Receptor, α2-Isotype

Clonality

Monoclonal

Isotype

IgG1

Clone

1330

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the C-terminal region of human thyroid hormone receptor, α2-isotype, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Purified by Protein G.

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.