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Retinoid X Receptor, γ-Isotype Antibody

Product Specifications

Background

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The Retinoid X Receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .

Synonyms

MGC109416 antibody, NR2B3 antibody, Nuclear receptor subfamily 2 group B member 3 antibody, OTTHUMP00000060418 antibody, Retanoic X receptor gamma antibody, Retinoic acid receptor RXR gamma antibody, Retinoic acid receptor RXR-gamma antibody, Retinoid X receptor gamma antibody, RXR G antibody, RXR gamma antibody, RXRC antibody, Rxrg antibody, RXRG_HUMAN antibody, RXRgamma antibody

Gene ID

6258

Swiss Prot

P48443

Host

Mouse

Cross Reactivity

Human, Rat

Target

Retinoid X Receptor, γ-Isotype

Clonality

Monoclonal

Isotype

IgG1

Clone

1373

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the hinge region of human retinoid X receptor, γ-isotype, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

WB

Purification

Purified by Protein G.

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Specificity

Specific for endogenous levels of the ~48 kDa RXR-γ isotype.

Gene ID URL

6258

Predicted Cross Reactivity

Mouse, Bovine, Non-Human Primate

Curated Selection

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