Retinoid X Receptor, γ-Isotype Antibody
Product Specifications
Background
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The Retinoid X Receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .
Synonyms
MGC109416 antibody, NR2B3 antibody, Nuclear receptor subfamily 2 group B member 3 antibody, OTTHUMP00000060418 antibody, Retanoic X receptor gamma antibody, Retinoic acid receptor RXR gamma antibody, Retinoic acid receptor RXR-gamma antibody, Retinoid X receptor gamma antibody, RXR G antibody, RXR gamma antibody, RXRC antibody, Rxrg antibody, RXRG_HUMAN antibody, RXRgamma antibody
Gene ID
6258
Swiss Prot
P48443
Host
Mouse
Cross Reactivity
Human, Rat
Target
Retinoid X Receptor, γ-Isotype
Clonality
Monoclonal
Isotype
IgG1
Clone
1373
Conjugation
Unconjugated
Source
Synthetic peptide corresponding to amino acid residues from the hinge region of human retinoid X receptor, γ-isotype, conjugated to keyhole limpet hemocyanin (KLH) .
Applications
WB
Purification
Purified by Protein G.
Concentration
Lot Dependent
Dilution
WB (1:300-5000)
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
Specific for endogenous levels of the ~48 kDa RXR-γ isotype.
Gene ID URL
6258
Predicted Cross Reactivity
Mouse, Bovine, Non-Human Primate
Curated Selection
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