Retinoid X Receptor, ß-Isotype Antibody

Product Specifications

Background

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .

Synonyms

DAUD I6 antibody, DAUDI6 antibody, H 2RIIBP antibody, H2RIIBP antibody, MGC1831 antibody, MHC class I promoter binding protein antibody, NR2B2 antibody, nuclear receptor subfamily 2 group B member 2 antibody, RCoR 1 antibody, RCoR1 antibody, Retinoic acid receptor RXR beta antibody, RXR beta antibody, RXRB antibody, RXRbeta antibody

Gene ID

6257

Swiss Prot

P28702

Host

Mouse

Cross Reactivity

Mouse, Rat

Target

Retinoid X Receptor, ß-Isotype

Clonality

Monoclonal

Isotype

IgG1

Clone

147

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the mouse retinoid X receptor, β- isotype, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

Purification

Purified by Protein G.

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.