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Retinoic Acid Receptor, ß-Isotype Antibody

Product Specifications

Background

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The Retinoid X receptors (RXRs) family (RXRα, β and γ) preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors (RARs) . RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .

Synonyms

HAP antibody, HBV-activated protein antibody, NR1B2 antibody, Nuclear receptor subfamily 1 group B member 2 antibody, RAR B antibody, RAR beta antibody, RAR epsilon antibody, RAR-beta antibody, RAR-epsilon antibody, RARB antibody, RARB_HUMAN antibody, Retinoic acid receptor beta 2 antibody, Retinoic acid receptor beta 4 antibody, Retinoic acid receptor beta 5 antibody, Retinoic acid receptor beta antibody, Retinoic acid receptor beta polypeptide antibody, RRB2 antibody

Gene ID

5915

Swiss Prot

P10826

Host

Mouse

Cross Reactivity

Human, Rat

Target

Retinoic Acid Receptor, ß-Isotype

Clonality

Monoclonal

Isotype

IgG1

Clone

336

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the N-terminal region of human Retinoic Acid Receptor, ß-Isotype, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

WB

Purification

Purified by Protein G.

Concentration

Lot dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Specificity

Specific for endogenous levels of the ~48 kDa RAR-ß isotype. The antigen is identical in both β1 and β2 isoforms.

Gene ID URL

5915

Predicted Cross Reactivity

Mouse, Dog, Guinea Pig, Non-Human Primate

Curated Selection

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