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Retinoic Acid Receptor, α-Isotype Antibody

Product Specifications

Background

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .

Synonyms

NR1B1 antibody, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody, Nuclear receptor subfamily 1 group B member 1 antibody, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody, RAR alpha antibody, RAR antibody, RAR-alpha antibody, rara antibody, RARA_HUMAN antibody, RARalpha antibody, RARalpha1 antibody, Retinoic acid nuclear receptor alpha variant 1 antibody, Retinoic acid nuclear receptor alpha variant 2 antibody, Retinoic acid receptor alpha antibody, Retinoic acid receptor alpha polypeptide antibody

Gene ID

5914

Swiss Prot

P10276

Host

Mouse

Cross Reactivity

Human, Mouse, Rat

Target

Retinoic Acid Receptor, α-Isotype

Clonality

Monoclonal

Isotype

IgG1

Clone

763

Conjugation

Unconjugated

Source

Synthetic peptide corresponding to amino acid residues from the N-terminal region of human retinoic acie receptor, α-isotype, conjugated to keyhole limpet hemocyanin (KLH) .

Applications

WB

Purification

Purified by Protein G.

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Modification

Unmodified

Storage Conditions

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Specificity

Specific for endogenous levels of the ~48 kDa RAR-α isotype.

Gene ID URL

5914

Predicted Cross Reactivity

Dog, Bovine, Guinea Pig

Curated Selection

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