Retinoic Acid Receptor, α-Isotype Antibody
Product Specifications
Background
Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005) . The retinoid X receptors (RXRs) family (RXRα, β and γ), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005) . RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005) .
Synonyms
NR1B1 antibody, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody, Nuclear receptor subfamily 1 group B member 1 antibody, Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody, RAR alpha antibody, RAR antibody, RAR-alpha antibody, rara antibody, RARA_HUMAN antibody, RARalpha antibody, RARalpha1 antibody, Retinoic acid nuclear receptor alpha variant 1 antibody, Retinoic acid nuclear receptor alpha variant 2 antibody, Retinoic acid receptor alpha antibody, Retinoic acid receptor alpha polypeptide antibody
Gene ID
5914
Swiss Prot
P10276
Host
Mouse
Cross Reactivity
Human, Mouse, Rat
Target
Retinoic Acid Receptor, α-Isotype
Clonality
Monoclonal
Isotype
IgG1
Clone
763
Conjugation
Unconjugated
Source
Synthetic peptide corresponding to amino acid residues from the N-terminal region of human retinoic acie receptor, α-isotype, conjugated to keyhole limpet hemocyanin (KLH) .
Applications
WB
Purification
Purified by Protein G.
Concentration
Lot Dependent
Dilution
WB (1:300-5000)
Buffer
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Modification
Unmodified
Storage Conditions
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Specificity
Specific for endogenous levels of the ~48 kDa RAR-α isotype.
Gene ID URL
5914
Predicted Cross Reactivity
Dog, Bovine, Guinea Pig
Curated Selection
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