Lamin A/C Antibody
Product Specifications
Background
Lamins A and C are nuclear structural proteins that are part of the intermediate filament family and coded for by the same gene (LMNA) . Lamins A and C are nearly identical except for their carboxy termini (McKeon et al., 1986) . Mutations in the gene encoding lamins A/C have been shown to cause a variety of diseases including autosomal dominant Emery-Dreifuss muscular dystrophy (Bonne et al., 1995), autosomal dominant limbgirdle muscular dystrophy (Muchir et al., 2000) and Charcot-Marie-Tooth disorder type 2 (De Sandre-Giavonnoli et al., 2002) .
Synonyms
70 kDa lamin antibody, Cardiomyopathy dilated 1A (autosomal dominant) antibody, CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, Lamin A antibody, Lamin A/C antibody, Lamin A/C like 1 antibody, Lamin antibody, Lamin C antibody, Lamin-A/C antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, Limb girdle muscular dystrophy 1B (autosomal dominant) antibody, LMN 1 antibody, LMN A antibody, LMN C antibody, LMN1 antibody, LMNA antibody, LMNA_HUMAN antibody, LMNC antibody, LMNL1 antibody, Prelamin A/C antibody, PRO1 antibody, Renal carcinoma antigen NY REN 32 antibody, Renal carcinoma antigen NY-REN-32 antibody, Renal carcinoma antigen NYREN32 antibody
Gene ID
4000
Swiss Prot
P02545
Host
Mouse
Cross Reactivity
Human
Target
Lamin A/C
Clonality
Monoclonal
Isotype
IgG1
Clone
4C4
Conjugation
Unconjugated
Source
Recombinant full length human lamin C expressed in and purified from E. Coli.
Applications
WB, IHC
Purification
Purified by Protein G.
Concentration
Lot Dependent
Dilution
WB (1:300-5000), IHC ()
Buffer
PBS + 10 mM NaN3.
Modification
Unmodified
Storage Conditions
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Specificity
Specific for endogenous levels of the ~64 kDa and ~74 kDa lamin A and C proteins.
Gene ID URL
4000
Curated Selection
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