COBRA1 (NELF-B) Antibody

Product Specifications

Background

COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004) . COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004)

Synonyms

A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Cofactor of BRCA1 antibody, DKFZp586B0519 antibody, KIAA1182 antibody, Negative elongation factor B antibody, Negative elongation factor protein B antibody, Nelf b antibody, NELF-B antibody, NELFB antibody, RGD1307832 antibody, RP13-122B23.3 antibody, RP23-132N23.4 antibody

Gene ID

25920

Swiss Prot

Q8WX92

Host

Mouse

Cross Reactivity

Human, Mouse, Rat

Target

COBRA1 (NELF-B)

Clonality

Monoclonal

Isotype

IgG1

Clone

F7E4

Conjugation

Unconjugated

Source

Recombinant full length human COBRA1 purified from E. coli.

Applications

Purification

Purified by Protein G.

Concentration

Lot Dependent

Dilution

WB (1:300-5000)

Buffer

PBS + 0.05% NaN3

Modification

Unmodified

Storage Conditions

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.