Tanshinone IIA

Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

Product Specifications

CAS Number

[568-72-9]

Product Name Alternative

Dan Shen ketone

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

VEGFR

Type

Natural Products

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Tanshinone-IIA.html

Purity

99.78

Solubility

DMF : 5 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 1 mg/mL (ultrasonic; warming; heat to 80°C) |Ethanol : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2C=CC3=C1CCCC3(C)C)C(C4=C2OC=C4C)=O

Molecular Formula

C19H18O3

Molecular Weight

294.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Xie J, et al. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5 (6) :554-63.|[2]Zhang Z, et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8 (7) :3124-32.|[3]Su CC, et al. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36 (2) :1173-9.|[4]Zhongyan Zhou, et al. Sodium tanshinone IIA sulfonate: a review of pharmacological activity and pharmacokinetics. Biomedicine & Pharmacotherapy 118 (2019) : 109362.