MEK5 Recombinant Antibody, APC-Cy5.5 Conjugated
Product Specifications
Background
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM.
Synonyms
MAP2K5; HsT17454; MAPKK 5; MEK 5; MAPKK5; MEK5; MKK5; MAP kinase kinase 5; PRKMK5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5.
Gene ID
5607
Swiss Prot
Q13163
Host
Rabbit
Cross Reactivity
Human
Target
MEK5
Clonality
Recombinant
Isotype
IgG
Conjugation
APC-Cy5.5
Source
KLH conjugated synthetic peptide derived from human MEK5
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
650nm/694nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
5607
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