4-Thiouracil

4-Thiouracil is a thionucleobase with cytostatic properties. 4-Thiouracil can be used as biological photoprobes to detect RNA structures and nucleic acid-nucleic acid contacts. 4-Thiouracil can also act as a strong ultraviolet A (UVA) photosensitizer, providing a source of the reactive oxygen species of O2. 4-Thiouracil is promising for research of photocross linking, photodamage, as well as photodynamic therapy[1].

Product Specifications

CAS Number

[591-28-6]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/4-thiouracil.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1)NC=CC1=S

Molecular Formula

C4H4N2OS

Molecular Weight

128.15

Precautions

H302+H312+H332

References & Citations

[1]Zou X, et al. Photophysical and photochemical properties of 4-thiouracil: time-resolved IR spectroscopy and DFT studies. J Phys Chem B. 2014 Jun 5;118 (22) :5864-72.