Phospho-TRIM28 (Ser824) Recombinant Antibody, Cy5 Conjugated
Product Specifications
Background
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) . Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me) ) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression.
Synonyms
KAP 1; KRAB associated protein 1; KRIP1; RNF96; TF1B; TIF1 beta; TIF1B; Trim28; Tripartite motif containing 28.
Gene ID
10155
Swiss Prot
Q13263
Modification Site
Ser824
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human
Target
TRIM28 (Ser824)
Clonality
Recombinant
Isotype
IgG
Conjugation
Cy5
Source
KLH conjugated synthetic peptide derived from human TIF1 beta around the phosphorylation site of S824
Applications
WB
Purification
Purified by Protein A.
Excitation Emission
625,650nm/670nm
Concentration
Lot dependent
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Phosphorylation
Storage Conditions
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Gene ID URL
10155
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