EGFR-PK/JNK-2-IN-1

EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2 with IC50s of 2.7 and 3.0 μM, respectively. EGFR-PK/JNK-2-IN-1 can induce apoptosis and induce cell cycle arrest at different cell phases. EGFR-PK/JNK-2-IN-1 can be used for the research of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR; JNK

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-pk-jnk-2-in-1.html

Solubility

10 mM in DMSO

Smiles

ClC(C=C1)=CC=C1C2=CC(C(NC3=CC=C(S(=O)(N)=O)C=C3)=O)=NN2C4=CC=CC=C4

Molecular Formula

C22H17ClN4O3S

Molecular Weight

452.91

References & Citations

[1]Soltan OM, et al. Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, moleecular docking, and bioactivity evaluation. Bioorg Med Chem Lett. 2024 Feb 24;102:129673.