EGFR-PK/JNK-2-IN-1
Product Specifications
UNSPSC Description
EGFR-PK/JNK-2-IN-1 (Compound 6c) is a dual inhibitor of EGFR-PK and JNK-2 with IC50s of 2.7 and 3.0 μM, respectively. EGFR-PK/JNK-2-IN-1 can induce apoptosis and induce cell cycle arrest at different cell phases. EGFR-PK/JNK-2-IN-1 can be used for the research of cancer[1].
Target Antigen
Apoptosis; EGFR; JNK
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-pk-jnk-2-in-1.html
Solubility
10 mM in DMSO
Smiles
ClC(C=C1)=CC=C1C2=CC(C(NC3=CC=C(S(=O)(N)=O)C=C3)=O)=NN2C4=CC=CC=C4
Molecular Weight
452.91
References & Citations
[1]Soltan OM, et al. Development of 1,5-diarylpyrazoles as EGFR/JNK-2 dual inhibitors: design, synthesis, moleecular docking, and bioactivity evaluation. Bioorg Med Chem Lett. 2024 Feb 24;102:129673.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162332/EGFR-PK-JNK-2-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162332/
Clinical Information
No Development Reported
Curated Selection
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