RNase L-IN-1
RNase L-IN-1 (compound 17a) is an inhibitor of RNase L, or Ribonuclease L. RNase L degrades RNAs to prevent viral replication, and mediates the innate immune responses and inflammation[1].
Product Specifications
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/rnase-l-in-1.html
Purity
98.08
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1/C(SC(NC2=CC(F)=CC=C2)=C1C(NCCN)=O)=C\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3
Molecular Formula
C27H35FN6O3S
Molecular Weight
542.67
References & Citations
[1]Hwang J, et al. Rational design and evaluation of 2- ((pyrrol-2-yl) methylene) thiophen-4-ones as RNase L inhibitors. Eur J Med Chem. 2023 Aug 5;256:115439.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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